The treatment of SARS-CoV2 with antivirals and mitigation of the cytokine storm syndrome: the role of gene expression

In the absence of a vaccine, treatment SARS-CoV2 has focused on eliminating virus with antivirals or mitigating cytokine storm syndrome (CSS) that leads to most common cause death: respiratory failure. Herein we discuss mechanisms antiviral treatments for and strategies CSS. Antivirals have shown in vitro activity against SARS-CoV2, closely related SARS-CoV1 MERS-CoV, are compared enzymatic level by potency cells. For CSS, medications reduce effects expression cytokines involved CSS an emphasis those IL-6 because its central role development We show some covered influence enzymes epigenetic processes specifically add remove modifications histones DNA. Where available, latest clinical data showing efficacy is presented. With respect their mechanisms, explain why successful, others failed, untested may yet prove useful.